Cyclic Citrullinated Peptide (CCP) Antibody (IgG)

Anti-Cyclic Citrullinated Peptide (Anti-CCP or ACPA) antibodies are autoantibodies highly specific for Rheumatoid Arthritis (RA). They often appear early in the disease course, sometimes even before symptoms, and are associated with more erosive joint damage. Testing for Anti-CCP alongside Rheumatoid Factor increases diagnostic accuracy for RA.