RPR (Rapid Plasma Reagin)

Rapid Plasma Reagin (RPR) is a nontreponemal screening test for syphilis that detects antibodies to cardiolipin. This test is used to screen for syphilis infection and monitor treatment response. Results are qualitative (reactive/nonreactive) with reflex to titer for positive results. A nonreactive result suggests no current syphilis infection, while a reactive result requires confirmatory treponemal testing. The test may have false positives in pregnancy, autoimmune conditions, or other infections.