Indirect Bilirubin

Indirect (Unconjugated) Bilirubin is calculated as Total Bilirubin minus Direct Bilirubin. It represents the bilirubin produced from heme breakdown before it is conjugated by the liver. Elevated indirect bilirubin (making up >75-80% of an elevated total bilirubin) typically indicates increased red blood cell destruction (hemolysis) or impaired liver uptake/conjugation (e.g., Gilbert's syndrome, neonatal jaundice, certain drugs).