Creatine Kinase (CK), MB

Creatine Kinase MB (CK-MB) is the myocardial-associated isoenzyme of creatine kinase. It has historically been used to help evaluate heart muscle injury and can still be useful alongside the clinical picture and other cardiac markers, especially when assessing timing or possible reinfarction. CK-MB is not fully heart-specific and can rise with significant skeletal muscle injury, so interpretation should consider symptoms, ECG findings, and other biomarkers.