Celiac Disease Comprehensive Panel

IgA antibodies against tissue transglutaminase (tTG) are highly specific serological markers for celiac disease and dermatitis herpetiformis. Their presence is a strong indicator of these autoimmune conditions. This test is the recommended first-line screening test for celiac disease in individuals who are not IgA deficient. Levels are expected to decrease on a gluten-free diet.

Immunoglobulin A (IgA) is a major antibody isotype found predominantly in mucosal secretions (e.g., saliva, tears, respiratory and gastrointestinal mucus) and also in serum. It plays a critical role in mucosal immunity, providing the first line of defense against inhaled and ingested pathogens. Serum IgA levels can be affected by various conditions. Selective IgA deficiency is the most common primary immunodeficiency.