Tissue Transglutaminase Ab, IgA

IgA antibodies against tissue transglutaminase (tTG) are highly specific serological markers for celiac disease and dermatitis herpetiformis. Their presence is a strong indicator of these autoimmune conditions. This test is the recommended first-line screening test for celiac disease in individuals who are not IgA deficient. Levels are expected to decrease on a gluten-free diet.