DHEA-Sulfate

DHEA-Sulfate (DHEA-S) is an abundant steroid hormone precursor produced almost exclusively by the adrenal glands. Levels peak in young adulthood and decline steadily with age (adrenopause). DHEA-S can be converted to androgens (like testosterone) and estrogens. Measurement helps evaluate adrenal function; high levels may indicate adrenal tumors or CAH, while low levels are common with aging but can also reflect adrenal insufficiency. Its role in supplementation for aging is debated.